Thermoactinoamide A, an Antibiotic Lipophilic Cyclopeptide from the Icelandic Thermophilic Bacterium Thermoactinomyces vulgaris

Roberta Teta, Viggó Thór Marteinsson, Arlette Longeon, Alexandra M. Klonowski, René Groben, Marie Lise Bourguet-Kondracki, Valeria Costantino, Alfonso Mangoni

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

16 Tilvitnanir (Scopus)

Útdráttur

The thermophilic bacterium Thermoactinomyces vulgaris strain ISCAR 2354, isolated from a coastal hydrothermal vent in Iceland, was shown to contain thermoactinoamide A (1), a new cyclic hexapeptide composed of mixed d and l amino acids, along with five minor analogues (2-6). The structure of 1 was determined by one- and two-dimensional NMR spectroscopy, high-resolution tandem mass spectrometry, and advanced Marfey's analysis of 1 and of the products of its partial hydrolysis. Thermoactinoamide A inhibited the growth of Staphylococcus aureus ATCC 6538 with an MIC value of 35 μM. On the basis of literature data and this work, cyclic hexapeptides with mixed d/l configurations, one aromatic amino acid residue, and a prevalence of lipophilic residues can be seen as a starting point to define a new, easily accessible scaffold in the search for new antibiotic agents.

Upprunalegt tungumálEnska
Síður (frá-til)2530-2535
Síðufjöldi6
FræðitímaritJournal of Natural Products
Bindi80
Númer tölublaðs9
DOI
ÚtgáfustaðaÚtgefið - 22 sep. 2017

Athugasemd

Funding Information:
We acknowledge the financial support of the European Union Seventh Framework Programme (BlueGenics, FP7-KBBE-2012-6) under grant agreement no. 311848 and by Università degli Studi di Napoli Federico II under the STAR project SeaLEADS.

Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.

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