The size of colon polyps revisited: Intra-and inter-observer variations

Carlos A. Rubio, Jon G. Jónasson, Gabriella Nesi, Joanna Mazur, Elínborg Ólafsdóttir

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

8 Tilvitnanir (Scopus)

Útdráttur

Background: It has been postulated that the occurrence of invasive carcinoma in a colon adenoma can be predicted by estimating the size of the resected polyp. Recently, significant intra- and inter-observer differences in size were found when 22 pathologists estimated the size of 12 polyp phantoms. In this work, the size of a large cohort of endoscopically-resected colon polyps was assessed with a novel method. Patients and Methods: Three pathologists measured photocopies of 148 resected polyps (adenomas at histology) in two independent trials. Results: The size recorded by the three participants was congruent in only 50% of the measurements in trial 1, and in 62% in trial 2. A significant difference in size asessment was found between the three investigators (p≤0.05). When 6 possible combinations (the 3 size limits proposed for predicting cancer risk in adenomas, and 2 different trials) were tested for the 13 adenomas showing invasive carcinoma, merely one of the three participants recorded the same size, but only in 11% of the 6 possible combinations. Conclusion: Present and previous investigations indicate that the lack of reproducibility makes the use of size limits in predicting cancer risk in polyps removed at colonoscopy unreliable.

Upprunalegt tungumálEnska
Síður (frá-til)2419-2423
Síðufjöldi5
FræðitímaritAnticancer Research
Bindi30
Númer tölublaðs6
ÚtgáfustaðaÚtgefið - jún. 2010

Fingerprint

Sökktu þér í rannsóknarefni „The size of colon polyps revisited: Intra-and inter-observer variations“. Saman myndar þetta einstakt fingrafar.

Vitna í þetta