Structural modification induced hydrogelation and antibacterial properties in supramolecular gels

Dipankar Ghosh, Pooja Chaudhary, Aathira Pradeep, Surendra Singh, Jayakumar Rangasamy, Krishna K. Damodaran*

*Fyrsti höfundur fyrir þetta verk

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

Útdráttur

Low molecular weight N-oxide hydrogelators were synthesized by incorporating N-oxide moieties into hydrazone/semicarbazone groups, which was obtained by the modification of the pyridyl functional groups of hydrazone/semicarbazone compounds. The properties of the N-oxide compounds were compared with the pyridyl compounds, and the results showed that the structural modification of the pyridyl-hydrazides to pyridyl-N-oxide hydrazides enhanced the water solubility of the hydrazone gelator. The relative stability of the gels was analyzed by minimum gelation concentration, gel-to-sol transition temperature and rheology, and the morphologies were analyzed by scanning electron microscope (SEM). The stimuli-responsive properties of the gels in the presence of various salts were analyzed by adding different potassium salts, and the hydrazone gels showed a selective response towards cyanide ion. The hydrazone gels displayed antibacterial activity against both Gram-positive and Gram-negative bacteria, whereas semicarbazone gels were inactive. Furthermore, the gels were found to be biocompatible, which can be used as antibacterial agents.

Upprunalegt tungumálEnska
Númer greinar122023
FræðitímaritJournal of Molecular Liquids
Bindi382
DOI
ÚtgáfustaðaÚtgefið - 15 júl. 2023

Athugasemd

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© 2023 Elsevier B.V.

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