Reconstruction of cellular signalling networks and analysis of their properties

Jason A. Papin, Tony Hunter, Bernhard O. Palsson, Shankar Subramaniam

Rannsóknarafurð: Framlag til fræðitímaritsYfirlitsgreinritrýni

384 Tilvitnanir (Scopus)

Útdráttur

The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

Upprunalegt tungumálEnska
Síður (frá-til)99-111
Síðufjöldi13
FræðitímaritNature Reviews Molecular Cell Biology
Bindi6
Númer tölublaðs2
DOI
ÚtgáfustaðaÚtgefið - feb. 2005

Athugasemd

Funding Information:
We would like to thank the Whitaker Foundation for a Graduate Fellowship to J.P., and acknowledge grants from the National Institutes of Health to S.S. T.H. is a Frank and Else Schilling American Cancer Society Research Professor. B.O.P. is a member of the Scientific Advisory Board of Genomatica Inc. We would also like to acknowledge valuable input from A. Hoffmann, and thank T. Allen, S. Becker, N. Price and J. Reed for detailed feedback on the manuscript.

Fingerprint

Sökktu þér í rannsóknarefni „Reconstruction of cellular signalling networks and analysis of their properties“. Saman myndar þetta einstakt fingrafar.

Vitna í þetta