New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe

M J Struelens, D L Monnet, A P Magiorakos, F Santos O'Connor, J Giesecke, K G Kristinsson, O Gudlaugsson, European NDM-1 Survey Participants

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

Útdráttur

Acquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat. A novel acquired carbapenemase, New Delhi metallo-beta-lactamase 1 (NDM-1), has recently been described in the United Kingdom and Sweden, mostly in patients who had received care on the Indian subcontinent. We conducted a survey among 29 European countries (the European Union Member States, Iceland and Norway) to gather information on the spread of NDM-1-producing Enterobacteriaceae in Europe, on public health responses and on available national guidance on detection, surveillance and control. A total of 77 cases were reported from 13 countries from 2008 to 2010. Klebsiella pneumoniae was the most frequently reported species with 54%. Among 55 cases with recorded travel history, 31 had previously travelled or been admitted to a hospital in India or Pakistan and five had been hospitalised in the Balkan region. Possible nosocomial acquisition accounted for 13 of 77 cases. National guidance on NDM-1 detection was available in 14 countries and on NDM-1 control in 11 countries. In conclusion, NDM-1 is spreading across Europe, where it is frequently linked to a history of healthcare abroad, but also to emerging nosocomial transmission. National guidance in response to the threat of carbapenemase-producing Enterobacteriaceae is available in approximately half of the surveyed European countries. Surveillance of carbapenemase- producing Enterobacteriaceae must be enhanced in Europe and effective control measures identified and implemented.
Upprunalegt tungumálEnska
FræðitímaritEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
ÚtgáfustaðaÚtgefið - 18 nóv. 2010

Önnur efnisorð

  • Public Health
  • Drug Resistance, Bacterial
  • Carbapenems
  • Enterobacteriaceae Infections
  • Polymerase Chain Reaction

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