Mathematical modelling of dynamics and control in metabolic networks. III. Linear reaction sequences

Bernhard O. Palsson, Hakon Palsson, Edwin N. Lightfoot

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

22 Tilvitnanir (Scopus)

Útdráttur

Kinetics of linear sequences of enzymatic reactions converting a single substrate into a single product are examined with emphasis on obtaining the relationship between the individual kinetic parameters and overall dynamic behavior. Chains of reactions exhibiting irreversible Michaelis-Menten kinetics are examined via scaling, linearization and modal analysis. The modal analysis gives the conditions under which the quasi-steady state assumption is applicable for one reaction relative to another in such a reaction sequence. The linearized description permits characterization of the transient response in terms of temporal moments. The moments provide useful physical insight and also provide a basis for systematic model reduction.

Upprunalegt tungumálEnska
Síður (frá-til)231-259
Síðufjöldi29
FræðitímaritJournal of Theoretical Biology
Bindi113
Númer tölublaðs2
DOI
ÚtgáfustaðaÚtgefið - 21 mar. 1985

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