Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology.

Yangzhen Shao, Bjorn Redfors, David Benoist, Sigfus Gizurarson, Elmir Omerovic

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

Útdráttur

Arrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.
Upprunalegt tungumálEnska
FræðitímaritMolecular and Cellular Biochemistry
DOI
ÚtgáfustaðaÚtgefið - ágú. 2014

Önnur efnisorð

  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Arrhythmias, Cardiac
  • Ceramides
  • Fatty Acids, Nonesterified
  • Humans
  • Lipid Metabolism
  • Lysophosphatidylcholines
  • Molecular Targeted Therapy
  • Palmitoylcarnitine

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