Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks

Aline Simen Kapeu, Tapio Luostarinen, Egil Jellum, Joakim Dillner, Matti Hakama, Pentti Koskela, Per Lenner, Arthur Löve, Eija Mahlamaki, Steinar Thoresen, Laufey Tryggvadóttir, Göran Wadell, Linda Youngman, Matti Lehtinen

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

65 Tilvitnanir (Scopus)

Útdráttur

The strong correlation between smoking and exposure to oncogenic human papillomaviruses (HPVs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. Thus, the authors evaluated this role. Five large Nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). Serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. The samples were analyzed for cotinine (a biomarker of tobacco exposure) and antibodies to HPV types 16 and 18, herpes simplex virus type 2, and Chlamydia trachomatis. Smoking was associated with the risk of squamous cell carcinoma (SCC) among HPV16- and/or HPV18-seropositive heavy smokers (odds ratio = 2.7, 95% confidence interval: 1.7, 4.3). A similar risk of SCC (odds ratio = 3.2, 95% confidence interval: 2.6, 4.0) was found in heavy smokers after adjustment for HPV16/18 antibodies. The point estimates increased with increasing age at diagnosis and increasing cotinine level. This study confirms that smoking is an independent risk factor for cervical cancer/SCC in women infected with oncogenic HPVs. These findings emphasize the importance of cervical cancer prevention among women exposed to tobacco smoke.

Upprunalegt tungumálEnska
Síður (frá-til)480-488
Síðufjöldi9
FræðitímaritAmerican Journal of Epidemiology
Bindi169
Númer tölublaðs4
DOI
ÚtgáfustaðaÚtgefið - feb. 2009

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