Intestinal permeability and bacterial growth of the small bowel in patients with primary sclerosing cholangitis

Einar Björnsson, Anna Cederborg, Anders Åkvist, Magnus Simren, Per Ove Stotzer, Ingvar Bjarnason

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

49 Tilvitnanir (Scopus)

Útdráttur

Objective. Animal studies show that small intestinal bacterial overgrowth and infusion of bacterial antigens into portal blood cause hepatic histological changes similar to those seen in primary sclerosing cholangitis in man. It has been suggested that a similar mechanism involving bacterial overgrowth with increased small-bowel permeability may play a pathogenic role in patients with primary sclerosing cholangitis. Material and methods. Twenty-two patients with primary sclerosing cholangitis (13 M, 9 F, median age 37 years, range 21-74 years), 19 of whom (83%) had quiescent inflammatory bowel disease, were included in the study along with 18 healthy volunteers (9 F, 9 M, median age 36 years, range 23-80 years). Small-bowel bacterial overgrowth was denned as the presence of colonic flora > 105 colony-forming units (cfu)/ml from duodenal aspirations. Small-bowel intestinal permeability was assessed as the differential urinary excretion of lactulose/L-rhamnose. Results. Bacterial overgrowth was evident in one patient with primary sclerosing cholangitis (4.5%) (Enterobacter) and in none of the controls. Intestinal permeability in patients with primary sclerosing cholangitis (0.034 (0.026-0.041) (median, interquartile range (IQR)) did not differ significantly from that of the controls (0.033 (0.025-0.041). Conclusions. Small intestinal bacterial overgrowth and increased intestinal permeability does not seem to play an important pathogenic role in patients with primary sclerosing cholangitis.

Upprunalegt tungumálEnska
Síður (frá-til)1090-1094
Síðufjöldi5
FræðitímaritScandinavian Journal of Gastroenterology
Bindi40
Númer tölublaðs9
DOI
ÚtgáfustaðaÚtgefið - sep. 2005

Athugasemd

Funding Information:
This study was supported by the Faculty of Medicine, University of Gothenburg.

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