Immunologically active (1→3)-(1→4)-α-D-Glucan from Cetraria islandica

E. S. Olafsdottir, K. Ingolfsdottir, H. Barsett, B. Smestad Paulsen, K. Jurcic, H. Wagner

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

43 Tilvitnanir (Scopus)

Útdráttur

A polysaccharide, Ci-3, resembling isolichenan except with a much higher degree of polymerization, has been isolated from the water extract, as well as from the alkali extract, of the lichen Cetraria islandica (L.) using ethanol fractionation, dialysis, ion-exchange chromatography and gel filtration. The mean Mr. of Ci-3 was determined to be 2000 kD, compared to 6-8 kD reported for isolichenan. The structure of Ci-3 was elucidated and found to be composed of (1→3)- and (1→4)-α-D-glucopyranosyl units in the ratio of 2:1, using methanolysis, methylation analysis, optical rotation and NMR spectroscopy. The immunomodulating activity of Ci-3 was tested in an in vitro phagocytosis assay and anti-complementary, and proved to be active in both tests.

Upprunalegt tungumálEnska
Síður (frá-til)33-39
Síðufjöldi7
FræðitímaritPhytomedicine
Bindi6
Númer tölublaðs1
DOI
ÚtgáfustaðaÚtgefið - mar. 1999

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