Genetics in lymphomagenesis

Sigurdur Y. Kristinsson, Richard Rosenquist, Ola Landgren, Lynn R. Goldin, Magnus Björkholm

Rannsóknarafurð: Kafli í bók/skýrslu/ráðstefnuritiKafliritrýni

Útdráttur

Lymphoproliferative diseases include many different disease entities with distinct cells of origin, pathologies, risk factor profiles, and prognoses. Although lymphomas are grouped traditionally into non-Hodgkin and Hodgkin lymphomas, the WHO classification today separates lymphomas into three main groups, B-cell, T-/NK-cell and Hodgkin lymphomas, where each group includes multiple subtypes. For instance, B-cell lymphomas comprise entities such as follicular lymphomas, diffuse large B-cell lymphomas, chronic lymphocytic leukemia, and lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. The causes of lymphomas are mostly unknown; however, known risk factors include autoimmunity, infections, and heredity. This chapter will focus on familiality, define basic concepts in lymphomagenesis, and discuss important genetic events in specific lymphomas.

Upprunalegt tungumálEnska
Titill gistiútgáfuNeoplastic Diseases of the Blood
ÚtgefandiSpringer New York
Síður835-847
Síðufjöldi13
ISBN-númer (rafrænt)9781461437642
ISBN-númer (prentað)1461437636, 9781461437635
DOI
ÚtgáfustaðaÚtgefið - 1 nóv. 2013

Athugasemd

Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights reserved.

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