Genetic variants in ER cofactor genes and endometrial cancer risk

Yuqing Li, Hui Qi Low, Jia Nee Foo, Hatef Darabi, Kristjana Einarsdöttir, Keith Humphreys, Amanda Spurdle, Douglas F. Easton, Deborah J. Thompson, Alison M. Dunning, Paul D.P. Pharoah, Kamila Czene, Kee Seng Chia, Per Hall, Jianjun Liu

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

5 Tilvitnanir (Scopus)

Útdráttur

Given that the transcriptional regulatory activity of estrogen receptor (ER) is modulated by its biochemical cofactors, genetic variation within the ER cofactor genes may alter cellular response to estrogen exposure and consequently modify the risk for endometrial cancer. We genotyped 685 tagging SNPs within 60 ER cofactor genes in 564 endometrial cancer cases and 1,510 controls from Sweden, and tested their associations with the risk of endometrial cancer. We investigated the associations of individual SNPs by using a trend test as well as multiple SNPs within a gene or gene complex by using multi-variant association analysis. No significant association was observed for any individual SNPs or genes, but a marginal association of the cumulative genetic variation of the NCOA2 complex as a whole (NCOA2, CARM1, CREBBP, PRMT1 and EP300) with endometrial cancer risk was observed (Padjusted = 0.033). However, the association failed to be replicated in an independent European dataset of 1265 cases and 5190 controls (P = 0.71). The results indicate that common genetic variants within ER cofactor genes are unlikely to play a significant role in endometrial cancer risk in European population.

Upprunalegt tungumálEnska
Númer greinare42445
FræðitímaritPLoS ONE
Bindi7
Númer tölublaðs8
DOI
ÚtgáfustaðaÚtgefið - 2 ágú. 2012

Fingerprint

Sökktu þér í rannsóknarefni „Genetic variants in ER cofactor genes and endometrial cancer risk“. Saman myndar þetta einstakt fingrafar.

Vitna í þetta