Experimental ischemia induces cell mitosis in the adult rat retina

E. Stefansson, C. A. Wilson, T. Schoen, T. Kuwabara

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

112 Tilvitnanir (Scopus)

Útdráttur

Experimental occlusion of the central retinal vessels in albino rats followed by reperfusion for 2 or 4 days resulted in a highly active proliferative response. Mitotic figures were produced in retinal vascular cells, presumed Muller cells, retinal pigment epithelial cells, and possibly other cell populations in the retina. A large number of mitosis were observed in 60-100% of 50 experimental eyes with 2, 4 or 6 hr of experimental ischemia and 2 or 4 days of reperfusion and in none of the 37 control eyes. Autoradiography demonstrated 3H-thymidine uptake in the retina and in vascular cells on a trypsin digest preparation of the retina. Retinal ischemia followed by reperfusion leads to mitosis of retinal cells. This suggests a causal relationship in proliferative retinopathies where ischemia and cell proliferation coincide.

Upprunalegt tungumálEnska
Síður (frá-til)1050-1055
Síðufjöldi6
FræðitímaritInvestigative Ophthalmology and Visual Science
Bindi29
Númer tölublaðs7
ÚtgáfustaðaÚtgefið - 1988

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