Evaluating iodine deficiency in pregnant women and young infants - Complex physiology with a risk of misinterpretation

P. Laurberg, S. Andersen, R. I. Bjarnadóttir, A. Carlé, A. B. Hreidarsson, N. Knudsen, L. Ovesen, I. B. Pedersen, L. B. Rasmussen

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

50 Tilvitnanir (Scopus)

Útdráttur

Objective: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. Design: Review of the literature regarding the various methods available for assessing iodine status. Setting: Population surveys and research studies. Subjects: Pregnant women and young infants. Results: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (μg l-1) is not interchangeable with 24 h UI excretion (μg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. Conclusions: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.

Upprunalegt tungumálEnska
Síður (frá-til)1547-1552
Síðufjöldi6
FræðitímaritPublic Health Nutrition
Bindi10
Númer tölublaðs12 A
DOI
ÚtgáfustaðaÚtgefið - des. 2007

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