Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women

M. L. Østerdal, M. Strøm, Å K. Klemmensen, V. K. Knudsen, M. Juhl, T. I. Halldorsson, A. M. Nybo Andersen, P. Magnus, S. F. Olsen

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

47 Tilvitnanir (Scopus)

Útdráttur

Objective: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia. Design: Prospective cohort. Setting: Denmark. Population: A total of 85 139 pregnant Danish women, recruited between 1996 and 2002. Methods: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression. Main outcome measures: Pre-eclampsia and severe pre-eclampsia. Results: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85 139). Conclusions: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

Upprunalegt tungumálEnska
Síður (frá-til)98-107
Síðufjöldi10
FræðitímaritBJOG: An International Journal of Obstetrics and Gynaecology
Bindi116
Númer tölublaðs1
DOI
ÚtgáfustaðaÚtgefið - jan. 2009

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