Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells

Hekla Sigmundsdottir, Andrew Johnston, Johann Eli Gudjonsson, Helgi Valdimarsson

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

Útdráttur

At both cutaneous and mucosal sites, interleukin (IL)-10, IL-12 and transforming growth factor (TGF)-beta are important regulators of chronic inflammatory disease, where cutaneous lymphocyte-associated antigen (CLA) and alphaE integrin (CD103) may be expressed. Stimulation with streptococcal pyrogenic exotoxin C (SpeC) increased the expression of CD103 by CD8+ but not CD4+ T cells. While adding IL-12 augmented the expression of CLA, superantigen-induced expression of CD103 was markedly suppressed by IL-12, which could be reversed by TGF-beta. Antibodies against TGF-beta inhibited, and a combination of anti-TGF-beta and IL-12 completely abrogated the induced CD103 expression. IL-10 strongly decreased the frequency of CLA+ and although not increasing the frequency of CD103+CD8+ T cells, the amount of CD103 expressed per cell was markedly increased. Thus, the expression of CLA and CD103 may be antagonistically regulated by IL-10 and IL-12 and the balance between these cytokines could influence the T cell migration of inflammatory cells into epithelial tissues.
Upprunalegt tungumálEnska
FræðitímaritClinical immunology (Orlando, Fla.)
DOI
ÚtgáfustaðaÚtgefið - 1 apr. 2004

Önnur efnisorð

  • Antigens, CD
  • CD8-Positive T-Lymphocytes
  • Integrin alpha Chains
  • Interleukin-12
  • Membrane Glycoproteins
  • Superantigens

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