We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition cluster defined by MA, MD, SA and unprovoked seizures. Identifying the biological underpinnings this cluster may affect clinical diagnosis and treatment.
Funding and disclosures : This work was supported by a grant from the National Institute of Neurological Disorders and Stroke (5R01 NS 32663). The authors thank Ingigerđur Olafsdóttir, Oddńy Gunnarsdóttir, and Ingibjörg Einarsdóttir for their assistance with the study. We are grateful also to Drs. Mervyn Susser and Anne T. Berg for their critical reading of the manuscript.