Characterizing phenotypic plasticity: A phase plane analysis

Jeremy S. Edwards, Ramprasad Ramakrishna, Bernhard O. Palsson

Rannsóknarafurð: Kafli í bók/skýrslu/ráðstefnuritiRáðstefnuframlagritrýni

2 Tilvitnanir (Scopus)

Útdráttur

Flux-balance analysis (FBA) was used to map the optimal metabolic phenotypes expressed by a genotype, under different environments. A finite number of optimal phenotypes were found and they were confined to specific regions in a plane formed by the values of two environmental variables, represented as uptake rates. The analysis was performed for growth on two different carbon sources (acetate and glucose) at various levels of oxygenation. It was determined, that there are a number of distinct optimal metabolic phenotypes expressed under varying carbon-oxygen limitations. These in silico results lead to a mechanistic interpretation of environmental factors on the complex genotype-phenotype relation and characterize the phenotypic plasticity of the organism.

Upprunalegt tungumálEnska
Titill gistiútgáfuAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ÚtgefandiIEEE
Síður1217
Síðufjöldi1
ISBN-númer (prentað)0780356756
ÚtgáfustaðaÚtgefið - 1999
ViðburðurProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Tímalengd: 13 okt. 199916 okt. 1999

Ritröð

NafnAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Bindi2
ISSN-númer (prentað)0589-1019

Ráðstefna

RáðstefnaProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Borg/bærAtlanta, GA, USA
Tímabil13/10/9916/10/99

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