Bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal single-center study

Christian Kjellander, Magnus Björkholm, Owe Källman, Christian G. Giske, Caroline E. Weibull, Thorvardur J. Löve, Ola Landgren, Sigurdur Y. Kristinsson

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

7 Tilvitnanir (Scopus)

Útdráttur

Infectious complications in chronic lymphocytic leukemia (CLL) represent a major cause of morbidity and mortality. The aim of the study was to investigate temporal trends in bloodstream infections (BSIs) among patients with CLL. Individuals with blood cultures were linked to Swedish Cancer Registry and divided into three time periods (1988–1993, 1994–1999, and 2000–2006) according to year of CLL diagnosis. CLL patients (n = 275) with 1092 blood culture episodes were identified and linked to the nationwide Cause of Death Registry and Swedish Patient Registry (to retrieve information on splenectomies). The most common causes of BSI among CLL patients were Escherichia coli (11/43, 15/78, and 9/33), Streptococcus pneumoniae (7/43, 13/78, and 6/33), Pseudomonas aeruginosa (2/43, 8/78, and 3/33), Staphylococcus aureus (1/43, 6/78, and 6/33), and Viridans streptococci (5/43, 6/78, and 2/33). Coagulase-negative staphylococci was the most frequent microorganism found in blood cultures (22/70, 23/106, and 5/41, respectively) but is a frequent contaminant. Based on the largest study to date on BSI in CLL patients, we found a stable proportion of Gram-positive to Gram-negative bacteria and no temporal change of distribution was observed for BSIs 1988–2006.

Upprunalegt tungumálEnska
Síður (frá-til)871-879
Síðufjöldi9
FræðitímaritAnnals of Hematology
Bindi95
Númer tölublaðs6
DOI
ÚtgáfustaðaÚtgefið - 1 maí 2016

Athugasemd

Funding Information:
We would like to thank Blodcancerfonden, the Swedish Cancer Society, the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet, the Karolinska Institutet Foundations, Adolf H. Lundin Charitable Foundation, Cathrine Everts Research Foundation, the University of Iceland Research Fund, Icelandic Centre for Research (RANNIS), and Landspitali University Hospital Research Fund.

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.

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