Associations of in Utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men

Anne Vested, Cecilia Høst Ramlau-Hansen, Sjurdur Frodi Olsen, Jens Peter Bonde, Susanne Lund Kristensen, Thorhallur Ingi Halldorsson, Georg Becher, Line Småstuen Haug, Emil Hagen Ernst, Gunnar Toft

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

129 Tilvitnanir (Scopus)

Útdráttur

Background: Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are found globally in humans; because they readily cross the placental barrier, in utero exposure may be a cause for concern. Objectives: We investigated whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels. Methods: We recruited 169 male offspring (19-21 years of age) from a pregnancy cohort established in Aarhus, Denmark, in 1988-1989, corresponding to 37.6% of the eligible sons. Each man provided a semen sample and a blood sample. Semen samples were analyzed for sperm concentration, total sperm count, motility, and morphology, and blood samples were used to measure reproductive hormones. As a proxy for in utero exposure, PFOA and PFOS were measured in maternal blood samples from pregnancy week 30. Results: Multivariable linear regression analysis suggested that in utero exposure to PFOA was associated with lower adjusted sperm concentration (ptrend = 0.01) and total sperm count (ptrend = 0.001) and with higher adjusted levels of luteinizing hormone (ptrend = 0.03) and follicle- stimulating hormone (ptrend = 0.01). PFOS did not appear to be associated with any of the outcomes assessed, before or after adjustment. Conclusions: The results suggest that in utero exposure to PFOA may affect adult human male semen quality and reproductive hormone levels.

Upprunalegt tungumálEnska
Síður (frá-til)453-458
Síðufjöldi6
FræðitímaritEnvironmental Health Perspectives
Bindi121
Númer tölublaðs4
DOI
ÚtgáfustaðaÚtgefið - apr. 2013

Önnur efnisorð

  • Umhverfisáhrif
  • Kynfrumur
  • Karlar
  • Meðganga
  • Alkanesulfonic Acids
  • Caprylates
  • Chromatography, Liquid
  • Cohort Studies
  • Denmark
  • Endocrine Disruptors
  • Environmental Exposure
  • Female
  • Fluorocarbons
  • Gonadal Steroid Hormones
  • Humans
  • Linear Models
  • Luminescent Measurements
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Prospective Studies
  • Semen
  • Semen Analysis
  • Sperm Count
  • Tandem Mass Spectrometry
  • Testis
  • Young Adult

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