Absence of meningeal mast cells in the Mitf mutant mouse

Alba Sabaté San José, Petur Henry Petersen*

*Fyrsti höfundur fyrir þetta verk

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

6 Niðurhal (Pure)

Útdráttur

Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.

Upprunalegt tungumálEnska
Númer greinar1337621
FræðitímaritFrontiers in Cellular Neuroscience
Bindi18
DOI
ÚtgáfustaðaÚtgefið - 2024

Athugasemd

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Copyright © 2024 Sabaté San José and Petersen.

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