Útdráttur
Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.
Upprunalegt tungumál | Enska |
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Númer greinar | 1337621 |
Fræðitímarit | Frontiers in Cellular Neuroscience |
Bindi | 18 |
DOI | |
Útgáfustaða | Útgefið - 2024 |
Athugasemd
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