A genome-scale, constraint-based approach to systems biology of human metabolism

Monica L. Mo, Neema Jamshidi, Bernhard Palsson

Rannsóknarafurð: Framlag til fræðitímaritsGreinritrýni

45 Tilvitnanir (Scopus)

Útdráttur

The recent sequencing and annotation of the human genome enables a new era in biomedicine that will be based on an interdisciplinary, systemic approach to the elucidation and treatment of human disease. Reconstruction of genome-scale metabolic networks is an important part of this approach since networks represent the integration of diverse biological data such as genome annotations, high-throughput data, and legacy biochemical knowledge. This article will describe Homo sapiens Recon 1, a functionally tested, genome-scale reconstruction of human cellular metabolism, and its capabilities for facilitating the understanding of physiological and disease metabolic states.

Upprunalegt tungumálEnska
Síður (frá-til)598-603
Síðufjöldi6
FræðitímaritMolecular BioSystems
Bindi3
Númer tölublaðs9
DOI
ÚtgáfustaðaÚtgefið - 2007

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