What causes Waldenström's macroglobulinemia: Genetic or immune-related factors, or a combination?

Sigurdur Y. Kristinsson; Ola Landgren

doi:10.3816/CLML.2011.n.015

What causes Waldenström's macroglobulinemia: Genetic or immune-related factors, or a combination?

Sigurdur Y. Kristinsson, Ola Landgren

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Population-based studies suggest a role for chronic immune stimulation and genetic factors in the causation of lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM). In this review we summarize and discuss our current understanding on etiology and pathogenesis of LPL/WM. We also highlight on gaps in the literature and propose future directions for population-based and molecular studies designed to expand our knowledge and uncover biological underpinnings of identified associations. Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

Original language	English
Pages (from-to)	85-87
Number of pages	3
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	11
Issue number	1
DOIs	https://doi.org/10.3816/CLML.2011.n.015
Publication status	Published - 1 Feb 2011

Bibliographical note

Funding Information:
This research was supported by grants from the Swedish Cancer Society, Stockholm County Council, the Karolinska Institutet Foundations, and the Intramural Research Program of the NIH, NCI.

Access to Document

10.3816/CLML.2011.n.015

Cite this

@article{b59d645b183a4234a6982a346b2c7953,

title = "What causes Waldenstr{\"o}m's macroglobulinemia: Genetic or immune-related factors, or a combination?",

abstract = "Population-based studies suggest a role for chronic immune stimulation and genetic factors in the causation of lymphoplasmacytic lymphoma (LPL)/Waldenstr{\"o}m's macroglobulinemia (WM). In this review we summarize and discuss our current understanding on etiology and pathogenesis of LPL/WM. We also highlight on gaps in the literature and propose future directions for population-based and molecular studies designed to expand our knowledge and uncover biological underpinnings of identified associations. Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.",

author = "Kristinsson, {Sigurdur Y.} and Ola Landgren",

note = "Funding Information: This research was supported by grants from the Swedish Cancer Society, Stockholm County Council, the Karolinska Institutet Foundations, and the Intramural Research Program of the NIH, NCI. ",

year = "2011",

month = feb,

day = "1",

doi = "10.3816/CLML.2011.n.015",

language = "English",

volume = "11",

pages = "85--87",

journal = "Clinical Lymphoma, Myeloma and Leukemia",

issn = "2152-2650",

publisher = "Cancer Media Group",

number = "1",

}

TY - JOUR

T1 - What causes Waldenström's macroglobulinemia

T2 - Genetic or immune-related factors, or a combination?

AU - Kristinsson, Sigurdur Y.

AU - Landgren, Ola

N1 - Funding Information: This research was supported by grants from the Swedish Cancer Society, Stockholm County Council, the Karolinska Institutet Foundations, and the Intramural Research Program of the NIH, NCI.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Population-based studies suggest a role for chronic immune stimulation and genetic factors in the causation of lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM). In this review we summarize and discuss our current understanding on etiology and pathogenesis of LPL/WM. We also highlight on gaps in the literature and propose future directions for population-based and molecular studies designed to expand our knowledge and uncover biological underpinnings of identified associations. Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

AB - Population-based studies suggest a role for chronic immune stimulation and genetic factors in the causation of lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM). In this review we summarize and discuss our current understanding on etiology and pathogenesis of LPL/WM. We also highlight on gaps in the literature and propose future directions for population-based and molecular studies designed to expand our knowledge and uncover biological underpinnings of identified associations. Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

UR - http://www.scopus.com/inward/record.url?scp=79953709727&partnerID=8YFLogxK

U2 - 10.3816/CLML.2011.n.015

DO - 10.3816/CLML.2011.n.015

M3 - Article

C2 - 21454199

AN - SCOPUS:79953709727

SN - 2152-2650

VL - 11

SP - 85

EP - 87

JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 1

ER -

What causes Waldenström's macroglobulinemia: Genetic or immune-related factors, or a combination?

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this