Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications

Cem Özçoban, Thomas Halbritter, Sabrina Steinwand, Lisa Marie Herzig, Jörg Kohl-Landgraf, Noushin Askari, Florian Groher, Boris Fürtig, Christian Richter, Harald Schwalbe, Beatrix Suess, Josef Wachtveitl*, Alexander Heckel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


The ultrafast photochemistry of a new spiropyran photoswitch (Py-BIPS) has been investigated, revealing many advantages in the application in water over the previously studied spiropyrans. Functionalized Py-BIPS derivatives are presented for the study of pH dependence, stability, toxicity, and the thermal and photochemical behavior on longer time scales in aqueous media using several spectroscopic methods. These investigations pave the way for the practical use of Py-BIPS derivatives as photoswitchable ligands of biomolecules.

Original languageEnglish
Pages (from-to)1517-1520
Number of pages4
JournalOrganic Letters
Issue number6
Publication statusPublished - 20 Mar 2015

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© 2015 American Chemical Society.


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