Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications

Cem Özçoban; Thomas Halbritter; Sabrina Steinwand; Lisa Marie Herzig; Jörg Kohl-Landgraf; Noushin Askari; Florian Groher; Boris Fürtig; Christian Richter; Harald Schwalbe; Beatrix Suess; Josef Wachtveitl; Alexander Heckel

doi:10.1021/acs.orglett.5b00397

Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications

Cem Özçoban, Thomas Halbritter, Sabrina Steinwand, Lisa Marie Herzig, Jörg Kohl-Landgraf, Noushin Askari, Florian Groher, Boris Fürtig, Christian Richter, Harald Schwalbe, Beatrix Suess, Josef Wachtveitl^*, Alexander Heckel

^*Corresponding author for this work

Science Institute

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The ultrafast photochemistry of a new spiropyran photoswitch (Py-BIPS) has been investigated, revealing many advantages in the application in water over the previously studied spiropyrans. Functionalized Py-BIPS derivatives are presented for the study of pH dependence, stability, toxicity, and the thermal and photochemical behavior on longer time scales in aqueous media using several spectroscopic methods. These investigations pave the way for the practical use of Py-BIPS derivatives as photoswitchable ligands of biomolecules.

Original language	English
Pages (from-to)	1517-1520
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	6
DOIs	https://doi.org/10.1021/acs.orglett.5b00397
Publication status	Published - 20 Mar 2015

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© 2015 American Chemical Society.

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abstract = "The ultrafast photochemistry of a new spiropyran photoswitch (Py-BIPS) has been investigated, revealing many advantages in the application in water over the previously studied spiropyrans. Functionalized Py-BIPS derivatives are presented for the study of pH dependence, stability, toxicity, and the thermal and photochemical behavior on longer time scales in aqueous media using several spectroscopic methods. These investigations pave the way for the practical use of Py-BIPS derivatives as photoswitchable ligands of biomolecules.",

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AU - Özçoban, Cem

AU - Halbritter, Thomas

AU - Steinwand, Sabrina

AU - Herzig, Lisa Marie

AU - Kohl-Landgraf, Jörg

AU - Askari, Noushin

AU - Groher, Florian

AU - Fürtig, Boris

AU - Richter, Christian

AU - Schwalbe, Harald

AU - Suess, Beatrix

AU - Wachtveitl, Josef

AU - Heckel, Alexander

PY - 2015/3/20

Y1 - 2015/3/20

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AB - The ultrafast photochemistry of a new spiropyran photoswitch (Py-BIPS) has been investigated, revealing many advantages in the application in water over the previously studied spiropyrans. Functionalized Py-BIPS derivatives are presented for the study of pH dependence, stability, toxicity, and the thermal and photochemical behavior on longer time scales in aqueous media using several spectroscopic methods. These investigations pave the way for the practical use of Py-BIPS derivatives as photoswitchable ligands of biomolecules.

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Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications

Abstract

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