Utilization of TBDMS chitosan for synthesis of photoactive chitosan derivatives and application in photografting on ophthalmic lens material

Priyanka Sahariah, Ana Paula Vieira, António Jorge Guiomar, Patrícia Alves, Már Másson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Three photoactive chitosan derivatives were synthesized using TBDMS chitosan as the starting material. In this study, we also report an optimized method for producing relatively high average molecular weight chitosan precursors for the synthesis of the three N-modified chitosan derivatives having a N-azidobenzoyl group, a N-methacryloyl group and a N-azidobenzoyl-N′,N′,N′-(acetyl-trimethyl ammoniumyl) group. The methacryloyl and azidobenzoyl derivatives synthesized were photografted onto discs of a crosslinked polymethacrylate copolymer used in the industrial production of intraocular lenses (IOLs), with dimensions comparable to those of IOLs. The photografted polymethacrylate was loaded with the antibiotic moxifloxacin, allowing the creation of an antibiotic releasing system that may be further developed for an application in postoperative endophthalmitis prophylaxis.

Original languageEnglish
Article number104600
JournalReactive and Functional Polymers
Volume153
DOIs
Publication statusPublished - Aug 2020

Bibliographical note

Funding Information:
We thank the financial support from the Icelandic Technical Development Fund (grant no. 13-1309 ) that was a part of jointly funded European M-ERA-NET project SurfLenses ( M-ERA.NET/0005/2012 ). This project was also supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal, and co-funded by the European Union through QREN, POFC-COMPETE and FEDER programs through research project M-ERA.NET/0006/2012012 , and by research project PTDC/CTM-BIO/3640/2014 (national funds). FCT funding from unit projects UID/EQU/00102/2013 for CIEPQPF and through personal grant SFRH/BPD/69410/2010 for postdoctoral studies (PA) is also acknowledged. The authors thank Maria Helena Gil (University of Coimbra) for advice in the photografting studies.

Funding Information:
We thank the financial support from the Icelandic Technical Development Fund (grant no. 13-1309) that was a part of jointly funded European M-ERA-NET project SurfLenses (M-ERA.NET/0005/2012). This project was also supported by Funda??o para a Ci?ncia e a Tecnologia (FCT), Portugal, and co-funded by the European Union through QREN, POFC-COMPETE and FEDER programs through research project M-ERA.NET/0006/2012012, and by research project PTDC/CTM-BIO/3640/2014 (national funds). FCT funding from unit projects UID/EQU/00102/2013 for CIEPQPF and through personal grant SFRH/BPD/69410/2010 for postdoctoral studies (PA) is also acknowledged. The authors thank Maria Helena Gil (University of Coimbra) for advice in the photografting studies.

Publisher Copyright:
© 2020 Elsevier B.V.

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