Urinary 6-sulfatoxymelatonin Levels and Prostate Cancer Risk among Men in the Multiethnic Cohort

Jane B. Vaselkiv, Iona Cheng, Ilkania M. Chowdhury-Paulino, Amparo G. Gonzalez-Feliciano, Lynne R. Wilkens, Alda M. Hauksdóttir, Gudny Eiriksdottir, Lo€c Le Marchand, Christopher A. Haiman, Unnur Valdimarsdóttir, Lorelei A. Mucci, Sarah C. Markt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The circadian hormone melatonin has anticancer properties, and prior studies suggest a positive association between low melatonin and prostate cancer risk. The purpose of this study was to examine urinary melatonin levels and prostate cancer in a racially/ethnically diverse cohort. Methods: We conducted a nested case–control study, including 1,263 prostate cancer cases and 2,346 controls, sampled from participants in the Multiethnic Cohort Study with prediagnostic urine samples assayed for 6-sulfatoxymelatonin, the primary melatonin metabolite. Conditional logistic regression was used to examine the association between melatonin levels and the development of prostate cancer outcomes (all incident cases, advanced, lethal, high-grade, and aggressive), overall and by race/ethnicity. Results: Among 1,263 cases, 135 were advanced stage, 101 were lethal cases, and 282 were high-grade disease. Median melatonin levels were similar in controls [17.12 ng/mL; interquartile range (IQR), 19.78] and cases (17.93 ng/mL; IQR, 19.76), and we found no significant association between urinary melatonin levels and prostate cancer risk overall or in any clinical or racial subgroup. Conclusions: In this diverse cohort, there was no significant association between melatonin and any prostate cancer outcome, nor were there any differences by racial/ethnic group. Impact: These results do not support a strong association between melatonin levels and risk of prostate cancer.

Original languageEnglish
Pages (from-to)688-691
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Mar 2022

Bibliographical note

Funding Information:
This study was funded by grants from the NCI. L.A. Mucci, U. Valdimarsdóttir, S.C. Markt, I. Cheng, and L.R. Wilkens are supported by R01 CA202690. L. Le Marchand, I. Cheng, and L.R. Wilkens are supported by U01 CA 164973. I.M. Chowdhury-Paulino is supported by T32 009001.

Publisher Copyright:
© 2021 American Association for Cancer Research.

Other keywords

  • Case-Control Studies
  • Cohort Studies
  • Humans
  • Male
  • Melatonin/analogs & derivatives
  • Prostatic Neoplasms
  • Risk Factors

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