Two intransal administration techniques give two different pharmacokinetic results

Sveinbjörn Gizurarson*, Erik Bechgaard, Rolf K. Hjortkjær

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Minor changes in the administration technique used for intranasal instillation of clonazepam, have been found to influence the results significantly. A simple study was performed, where rabbits received 0.5 mg clonazepam intranasally. One group received the drug while fixed in a sitting position, where the other group was fixed in a supine position. The results show that both techniques where able to provide a rapid absorption with a tmax around 3-4 min. The Cmax and AUC, however, were very different. The Cmax was found to be 40 ng/ml and 86 ng/ml, respectively, and the AUC was found to be 891 and 2249 (ng/ml/min), respectively, for the sitting and the supine position. The relative bioavailability for sitting/supine was found to be 38%. These results show that the administration technique is very important and should not be underestimated.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalScandinavian Journal of Laboratory Animal Science
Volume33
Issue number1
Publication statusPublished - 2006

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