Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia.

Lene Molgaard-Hansen, Merja Möttönen, Heidi Glosli, Guðmundur K Jónmundsson, Jonas Abrahamsson, Henrik Hasle

Research output: Contribution to journalArticlepeer-review

Abstract

The frequency and causes of treatment-related deaths (TRD) in second complete remission (CR2) in acute myeloid leukaemia (AML) were investigated in a historical, prospective cohort study of 429 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-88 and -93 trials. Relapse occurred in 158 children (39%). Seventeen (18%) of the 96 patients entering CR2 suffered TRD. The main causes were infection (59%) and complications from graft-versus-host disease (22%). Fourteen (82%) of 17 TRDs occurred in children undergoing haematopoietic stem cell transplantations (HSCT). Optimal supportive care after HSCT is essential, and studies on risk factors for TRD are needed.
Original languageEnglish
JournalBritish Journal of Haematology
DOIs
Publication statusPublished - Mar 2011

Other keywords

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols
  • Child
  • Child, Preschool
  • Disease Progression
  • Epidemiologic Methods
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute
  • Male
  • Opportunistic Infections
  • Recurrence
  • Remission Induction
  • Scandinavia

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