The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species

Alina-Andreea Zimta, Olafur Eysteinn Sigurjonsson, Diana Gulei, Ciprian Tomuleasa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Nowadays, advancements in the oncology sector regarding diagnosis methods allow us to specifically detect an increased number of cancer patients, some of them in incipient stages. However, one of the main issues consists of the invasive character of most of the diagnosis protocols or complex medical procedures associated with it, that impedes part of the patients to undergo routine checkups. Therefore, in order to increase the number of cancer cases diagnosed in incipient stages, other minimally invasive alternatives must be considered. The current review paper presents the value of rare RNA species isolated from circulatory exosomes as biomarkers of diagnosis, prognosis or even therapeutic intervention. Rare RNAs are most of the time overlooked in current research in favor of the more abundant RNA species like microRNAs. However, their high degree of stability, low variability and, for most of them, conservation across species could shift the interest toward these types of RNAs. Moreover, due to their low abundance, the variation interval in terms of the number of sequences with differential expression between samples from healthy individuals and cancer patients is significantly diminished and probably easier to interpret in a clinical context.
Original languageEnglish
Article number5866
Number of pages5866
JournalInternational Journal of Molecular Sciences
Issue number16
Publication statusPublished - 15 Aug 2020

Other keywords

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Molecular Biology
  • Catalysis
  • Exosomes
  • snRNA
  • snoRNA
  • piRNA
  • vRNA
  • yRNA
  • tRNA
  • Cancer
  • Eðlisefnafræði
  • Lífræn efnafræði
  • Ólífræn efnafræði
  • Sameindalíffræði
  • Litrófsgreining
  • Efnahvatar
  • Frumur
  • RNA kjarnsýra
  • Krabbamein


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