The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L

Steinthor Sigurdsson*, Helga M. Ögmundsdottir, Sigmundur Gudbjarnason

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Background: The aim of this work was to study the constituents and cytotoxicity of the essential oils from the fruits of Angelica archangelica growing in Iceland. Materials and Methods: Three samples of essential oils were prepared by steam distillation. Their composition was established with GC/MS. The effects of the oils were examined in PANC-1 human pancreas cancer cells and Crl mouse breast cancer cells in concentrations ranging from 10-400 μg/ml, measuring the reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-5- (3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) by mitochondrial enzymes. Results: Two types of essential oils were found, differing mainly in the absence or presence of β-phellandrene. The ED 50 of the oils ranged from 48.6 μg/m/ to 108.3 μg/ml for PANC-1 and 48.0 μg/ml to 91.8 μg/ml for Crl cells. Conclusion: The cytotoxic activity of the essential oils was independent of the quantity of their main components.

Original languageEnglish
Pages (from-to)1877-1880
Number of pages4
JournalAnticancer Research
Volume25
Issue number3 B
Publication statusPublished - May 2005

Other keywords

  • β-phellandrene
  • A. Archangelica
  • Crl
  • Cytotoxicity
  • Essential oils

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