Abstract
Background: Type 2 diabetes is one of the first success stories in the application of genome-wide linkage and association studies to find genetic variants contributing to its risk. Objective: Are the genetic markers found so far useful in predicting which individuals are more likely to develop type 2 diabetes? Can they find which patients with prediabetes are more likely to convert to type 2 diabetes and therefore may benefit the most from lifestyle or pharmacologic prevention strategies? Methods: The literature pertaining to the discovery and replications of genes contributing to type 2 diabetes was focused on. Results/conclusion: Substantial risk for type 2 diabetes is represented by the top 8 genes, including TCF7L2, and in certain circumstances may be useful for prevention strategies targeted to those with highest risk.
| Original language | English |
|---|---|
| Pages (from-to) | 991-1002 |
| Number of pages | 12 |
| Journal | Expert Opinion on Medical Diagnostics |
| Volume | 2 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2008 |
Other keywords
- Impaired fasting glucose
- Prediabetes
- Prevention
- Risk
- TCF7L2
- Type 2 diabetes