The biomass objective function

Adam M. Feist; Bernhard O. Palsson

doi:10.1016/j.mib.2010.03.003

The biomass objective function

Adam M. Feist^*, Bernhard O. Palsson

^*Corresponding author for this work

University of Iceland

Research output: Contribution to journal › Review article › peer-review

351 Citations (Scopus)

Abstract

Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

Original language	English
Pages (from-to)	344-349
Number of pages	6
Journal	Current Opinion in Microbiology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.mib.2010.03.003
Publication status	Published - Jun 2010

Bibliographical note

Funding Information:
We would like to thank Jacob D Feala and Daniel C Zielinski for their valuable feedback on this manuscript. Studies performed at UCSD were supported by National Institutes of Health Grant R01 GM057089.

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10.1016/j.mib.2010.03.003

Cite this

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abstract = "Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.",

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AB - Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

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DO - 10.1016/j.mib.2010.03.003

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JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

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The biomass objective function

Abstract

Bibliographical note

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