Systems biology as a foundation for genome-scale synthetic biology

Christian L. Barrett*, Tae Yong Kim, Hyun Uk Kim, Bernhard Palsson, Sang Yup Lee

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)


As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalCurrent Opinion in Biotechnology
Issue number5
Publication statusPublished - Oct 2006

Bibliographical note

Funding Information:
The work of SYL was supported by the Korean Systems Biology Research Project (M10309020000–03B5002–00000) of the Ministry of Science and Technology, the BK21 Project, and by the LG Chem Chair Professorship.


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