Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.

Margrét Þorsteinsdóttir, J. Singh, Wayne Zeller, Nian Zhou, Georgeta Hategen, Rama Mishra, Alex Polozov, Peng Yu, Emmanuel Onua, J. Zhang, José L. Ramírez, G. Sigthorsson, A. S. Kiselyov, D. E. Zembower, T. Andresson, M. E. Gurney

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)18-36
JournalJournal of Medicinal Chemistry
Publication statusPublished - 2010

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