Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of genetic differences between two populations exchanging migrants. Here we explore the dynamics of an underdominant system in a network of multiple discrete, yet interconnected, populations. Stability of genetic differences in response to increases in migration in various topological networks is assessed. The network topology can have a dominant and occasionally non-intuitive influence on the genetic stability of the system.
Bibliographical noteFunding Information:
Funding: This work was supported by a grant to ÁJL from the Charles H. and Margaret B. Edmondson Research Fund and a grant to FAR (12ADVC-51343) from the Victoria S. and Bradley L. Geist Foundation administered by the Hawai׳i Community Foundation Medical Research Program , 12ADVC-51343 .
© 2015 Elsevier Ltd.
- Coordination game
- Dynamical system
- Network topology
- Population genetics