Stability of underdominant genetic polymorphisms in population networks

Áki Jarl Láruson, Floyd A. Reed*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of genetic differences between two populations exchanging migrants. Here we explore the dynamics of an underdominant system in a network of multiple discrete, yet interconnected, populations. Stability of genetic differences in response to increases in migration in various topological networks is assessed. The network topology can have a dominant and occasionally non-intuitive influence on the genetic stability of the system.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJournal of Theoretical Biology
Publication statusPublished - 7 Feb 2016

Bibliographical note

Funding Information:
Funding: This work was supported by a grant to ÁJL from the Charles H. and Margaret B. Edmondson Research Fund and a grant to FAR (12ADVC-51343) from the Victoria S. and Bradley L. Geist Foundation administered by the Hawai׳i Community Foundation Medical Research Program , 12ADVC-51343 .

Publisher Copyright:
© 2015 Elsevier Ltd.

Other keywords

  • Coordination game
  • Dynamical system
  • Network topology
  • Population genetics
  • Underdominance


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