Sonoelastografske karakteristike lezija dojke visokog rizika i duktalnog karcinoma in situ – probno istraživanje

Translated title of the contribution: Sonoelastographic features of high-risk breast lesions and ductal carcinoma in situ – a pilot study

Maja Crnogorac*, Gordana Ivanac, Čedna Tomasović-Lončarić, Rado Žic, Tomislav Kelava, Boris Brkljačić

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of this study was to evaluate the quantitative sonoelastographic values recorded on shear-wave sonoelastography (SWE) of high-risk breast lesions and ductal carcinoma in situ (DCIS). We retrospectively analyzed histopathologic and SWE data (quantitative maximum, minimum and mean stiffness, lesion-to-fat ratio (E-ratio), lesion size) of 228 women referred to our Department for core needle breast biopsy during a four-year period. Among 230 lesions, histopathologic findings showed 34 high-risk breast lesions and 29 DCIS, which were compared with 167 ductal invasive carcinomas. High-risk lesions had lower values of all sonoelastographic features than ductal in situ and invasive carcinoma, however, only E-ratio showed a statistically significant difference in comparison to DCIS (3.7 vs. 6, p<0.001). All sonoelastographic features showed significant difference between in situ and invasive carcinoma. There was a significant correlation between lesion size and stiffness (r=0.36; p<0.001). Stiffness measured by SWE is an effective predictor of the histopathologic severity of sonographically detectable breast lesions. Elasticity values of high-risk lesions are significantly lower than those of malignant lesions. Furthermore, we showed that along with the sonographic appearance, which in most cases shows typical microcalcifications, DCIS had significantly different elasticity parameters than invasive carcinoma.

Translated title of the contributionSonoelastographic features of high-risk breast lesions and ductal carcinoma in situ – a pilot study
Original languageBosnian
Pages (from-to)13-22
Number of pages10
JournalActa Clinica Croatica
Volume58
Issue number1
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
The study was conducted as part of the project entitled Sonoelastography and MRI in Diagnosis and Treatment of Breast Cancer (IP 2016-06-2997) of the Croatian Science Foundation.

Publisher Copyright:
© 2019, Klinicka Bolnica Sestre Milosrdnice. All rights reserved.

Other keywords

  • Breast neoplasms
  • Carcinoma
  • Classification
  • Diagnostic imaging
  • Elastic moduluUltrasonography
  • Elasticity imaging techniques
  • Intra-ductal
  • Mammary
  • Sensitivity and specificity
  • Shear-wave elastography (SWE)

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