Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications

Rachel Shulman, Debbie L Cohen, Michael A Grandner, Thorarinn Gislason, Allan I Pack, Samuel T Kuna, Raymond R Townsend, Jordana B Cohen

Research output: Contribution to journalArticlepeer-review


Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure (BP) was 12.7 mm Hg higher in LIMBS (P < 0.001; n = 66) and 4.7 mm Hg higher in PISA (P = 0.005; n = 153) among participants with shorter sleep duration (less than 7 hours) compared to those with longer sleep duration (at least 7 hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic BP on 24-hour ABPM, independent of nocturnal BP and in-office BP. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease.
Original languageEnglish
Pages (from-to)1712-1720
JournalJournal of Clinical Hypertension
Issue number12
Publication statusPublished - 1 Dec 2018

Other keywords

  • ambulatory
  • blood pressure monitoring
  • circadian rhythm
  • hypertension
  • obstructive sleep apnea
  • sleep deprivation
  • sleep disorders
  • Svefn
  • Svefnleysi
  • Háþrýstingur
  • Sleep Deprivation
  • Blood Pressure


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