SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus.

J G Hanly, M B Urowitz, D Jackson, S C Bae, C Gordon, D J Wallace, A Clarke, S Bernatsky, A Vasudevan, D Isenberg, A Rahman, J Sanchez-Guerrero, J Romero-Diaz, J T Merrill, P R Fortin, D D Gladman, I N Bruce, K Steinsson, M Khamashta, G S AlarcónB Fessler, M Petri, S Manzi, O Nived, G Sturfelt, R Ramsey-Goldman, M A Dooley, C Aranow, R Van Vollenhoven, M Ramos-Casals, A Zoma, K Kalunian, V Farewell

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OBJECTIVE: To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). METHODS: An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. RESULTS: 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3 ± 2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p<0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were +1.73 (0.71) and -0.62 (1.58) (p<0.05), respectively. Changes in SF-36 subscales were in the same direction (p<0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. CONCLUSION: Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients.
Original languageEnglish
JournalAnnals of the Rheumatic Diseases
Publication statusPublished - Jun 2011

Other keywords

  • Adult
  • Female
  • Humans
  • Lupus Vasculitis, Central Nervous System
  • Male
  • Mental Disorders
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • Schools, Public Health
  • Severity of Illness Index
  • Treatment Outcome
  • Young Adult


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