TY - JOUR
T1 - Self-assembly of cyclodextrins: Formation of cyclodextrin polymer based nanoparticles
AU - Fülöp, Zoltán
AU - Kurkov, Sergey V.
AU - Nielsen, Thorbjørn Terndrup
AU - Larsen, Kim Lambertsen
AU - Loftsson, Þorsteinn
PY - 2012
Y1 - 2012
N2 - The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.
AB - The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84862850770&partnerID=MN8TOARS
U2 - 10.1016/S1773-2247(12)50032-8
DO - 10.1016/S1773-2247(12)50032-8
M3 - Article
SN - 1773-2247
VL - 22
SP - 215
EP - 221
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 3
ER -