SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells

Andrew B. Goldstone; Cassandra E. Burnett; Jeffery E. Cohen; Michael J. Paulsen; Anahita Eskandari; Bryan E. Edwards; Arnar B. Ingason; Amanda N. Steele; Jay B. Patel; John W. MacArthur; Judith A. Shizuru; Y. Joseph Woo

doi:10.1007/s12265-017-9772-y

SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells

Andrew B. Goldstone, Cassandra E. Burnett, Jeffery E. Cohen, Michael J. Paulsen, Anahita Eskandari, Bryan E. Edwards, Arnar B. Ingason, Amanda N. Steele, Jay B. Patel, John W. MacArthur, Judith A. Shizuru, Y. Joseph Woo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.

Original language	English
Pages (from-to)	274-284
Number of pages	11
Journal	Journal of Cardiovascular Translational Research
Volume	11
Issue number	4
DOIs	https://doi.org/10.1007/s12265-017-9772-y
Publication status	Published - 1 Aug 2018

Bibliographical note

Funding Information:
Funding Information This work was supported by the National Institutes of Health [R01 HL089315-01 to Y.J.W., S10OD010344-01A1 to Stanford Center for In Vivo Imaging] and the American Heart Association [14POST20380744 to A.B.G.]

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Other keywords

Angiogenesis
Bone marrow
Cell fusion
Myocardial infarction
Regeneration

Access to Document

10.1007/s12265-017-9772-y

Cite this

Goldstone, A. B., Burnett, C. E., Cohen, J. E., Paulsen, M. J., Eskandari, A., Edwards, B. E., Ingason, A. B., Steele, A. N., Patel, J. B., MacArthur, J. W., Shizuru, J. A., & Woo, Y. J. (2018). SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells. Journal of Cardiovascular Translational Research, 11(4), 274-284. https://doi.org/10.1007/s12265-017-9772-y

@article{d182a339f5c440b49e533dd60f01159b,

title = "SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells",

abstract = "Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.",

keywords = "Angiogenesis, Bone marrow, Cell fusion, Myocardial infarction, Regeneration",

author = "Goldstone, {Andrew B.} and Burnett, {Cassandra E.} and Cohen, {Jeffery E.} and Paulsen, {Michael J.} and Anahita Eskandari and Edwards, {Bryan E.} and Ingason, {Arnar B.} and Steele, {Amanda N.} and Patel, {Jay B.} and MacArthur, {John W.} and Shizuru, {Judith A.} and Woo, {Y. Joseph}",

note = "Funding Information: Funding Information This work was supported by the National Institutes of Health [R01 HL089315-01 to Y.J.W., S10OD010344-01A1 to Stanford Center for In Vivo Imaging] and the American Heart Association [14POST20380744 to A.B.G.] Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2018",

month = aug,

day = "1",

doi = "10.1007/s12265-017-9772-y",

language = "English",

volume = "11",

pages = "274--284",

journal = "Journal of Cardiovascular Translational Research",

issn = "1937-5387",

publisher = "Springer New York",

number = "4",

}

Goldstone, AB, Burnett, CE, Cohen, JE, Paulsen, MJ, Eskandari, A, Edwards, BE, Ingason, AB, Steele, AN, Patel, JB, MacArthur, JW, Shizuru, JA & Woo, YJ 2018, 'SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells', Journal of Cardiovascular Translational Research, vol. 11, no. 4, pp. 274-284. https://doi.org/10.1007/s12265-017-9772-y

TY - JOUR

T1 - SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells

AU - Goldstone, Andrew B.

AU - Burnett, Cassandra E.

AU - Cohen, Jeffery E.

AU - Paulsen, Michael J.

AU - Eskandari, Anahita

AU - Edwards, Bryan E.

AU - Ingason, Arnar B.

AU - Steele, Amanda N.

AU - Patel, Jay B.

AU - MacArthur, John W.

AU - Shizuru, Judith A.

AU - Woo, Y. Joseph

N1 - Funding Information: Funding Information This work was supported by the National Institutes of Health [R01 HL089315-01 to Y.J.W., S10OD010344-01A1 to Stanford Center for In Vivo Imaging] and the American Heart Association [14POST20380744 to A.B.G.] Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.

AB - Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). SDF was delivered post-MI, and hearts were evaluated for recruitment and plasticity of bone marrow-derived populations. SDF treatment improved ventricular function, border zone vessel density, and CD31+ cell frequency post-MI. Bone marrow-derived endothelial cells were observed; these cells arose through both cell fusion and transdifferentiation. Circulating cells also adopted cardiomyocyte fates, but such events were exceedingly rare and almost exclusively resulted from cell fusion. SDF did not significantly alter the proportion of circulating cells that adopted non-hematopoietic fates. Mechanistic insight into the governance of circulating cells is essential to realizing the full potential of cytokine therapies.

KW - Angiogenesis

KW - Bone marrow

KW - Cell fusion

KW - Myocardial infarction

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=85042220631&partnerID=8YFLogxK

U2 - 10.1007/s12265-017-9772-y

DO - 10.1007/s12265-017-9772-y

M3 - Article

C2 - 29468554

AN - SCOPUS:85042220631

SN - 1937-5387

VL - 11

SP - 274

EP - 284

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 4

ER -

SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells

Abstract

Bibliographical note

Other keywords

Access to Document

Fingerprint

Cite this