Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy

Nicola J. Allen, Ragnhildur Káradóttir, David Attwell*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. This dysfunction can comprise a reversal of transport direction, leading to the release of neurotransmitter into the extracellular space, or an alteration in transporter expression level. This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders.

Original languageEnglish
Pages (from-to)132-142
Number of pages11
JournalPflugers Archiv European Journal of Physiology
Volume449
Issue number2
DOIs
Publication statusPublished - Nov 2004

Other keywords

  • GABA
  • Glutamate
  • Neurodegeneration
  • Reversal
  • Transporter

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