Repetitive transcranial magnetic stimulation transiently reduces punding in Parkinson's disease: A preliminary study

Raffaele Nardone*, Pierpaolo De Blasi, Yvonne Höller, Monica Christova, Frediano Tezzon, Eugen Trinka, Francesco Brigo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Amongst the impulse-control disorders (ICDs) associated with dopamine-replacement therapy in patients with Parkinson's disease (PD) is a repetitive, complex, stereotyped behaviour called punding. Disruption of the reciprocal loops between the striatum and structures in the prefrontal cortex (PFC) following dopamine depletion may predispose patients with PD to these behavioural disorders. The purpose of the present study was to assess the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral PFC (DLPFC) on punding in PD. We used low-frequency (LF) rTMS in four PD patients presenting with punding. Punding was transiently reversed by LF-rTMS over the DLPFC without enhancing motor impairment. The effect was more sustained after right DLPFC rTMS. Therefore, LF-rTMS produced a transient beneficial effect in PD patients with punding, similar to that reported in PD patients with levodopa-induced dyskinesias. rTMS might have therapeutic potential for the treatment of punding and perhaps other ICDs in PD.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalJournal of Neural Transmission
Volume121
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Other keywords

  • Dorsolateral prefrontal cortex
  • Impulse control disorders
  • Parkinson's disease
  • Punding
  • Repetitive transcranial magnetic stimulation

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