TY - JOUR
T1 - Renal vascular resistance in autosomal dominant polycystic kidney disease
T2 - Evaluation with color doppler ultrasound
AU - Brkljacic, B.
AU - Sabljar-Matovinovic, M.
AU - Putarek, K.
AU - Soldo, D.
AU - Morovic-Vergles, J.
AU - Hauser, Markus
PY - 1997
Y1 - 1997
N2 - Purpose: The purpose of this study was to evaluate the performance of duplex Doppler ultrasonography in the assessment of renal vascular resistance (RVR) by measuring resistive indices (RIs) and pulsatility indices (PIs) in patients with autosomal dominant polycystic kidney disease (ADPKD), and to correlate the measured values with renal function and the presence of arterial hypertension. Materials and Methods: In 42 patients with ADPKD and 65 control subjects, RIs and PIs were measured by means of color duplex Doppler sonography and correlated with clinical and laboratory findings and with morpological abnormalities at B-mode ultrasonography. Results: Mean RI in the control subjects was 0.59±0.03 (±SD) and in the patients 0.71±0.11, (p<0.01). Mean PI in the controls was 1.00±0.11 and in the patients 1.69±0.21, (p<0.01). Elevated RIs and PIs heralded a progression of ADPKD. Doppler indices correlated significantly with renal function tests and morphological changes in the affected kidneys at ultrasound. Significantly higher RIs (p<0.01) and PIs (p<0.04) were measured in hypertensive ADPKD patients as compared to normotensive patients. Correlation of patient age and Doppler indices did not reach statistical significance. Conclusion: Doppler indices do reflect the increased RVR in patients with ADPKD and they correlate with renal function disturbance, with the development of systematic arterial hypertension, and with ultrasonographic abnormality of the kidney in these subjects.
AB - Purpose: The purpose of this study was to evaluate the performance of duplex Doppler ultrasonography in the assessment of renal vascular resistance (RVR) by measuring resistive indices (RIs) and pulsatility indices (PIs) in patients with autosomal dominant polycystic kidney disease (ADPKD), and to correlate the measured values with renal function and the presence of arterial hypertension. Materials and Methods: In 42 patients with ADPKD and 65 control subjects, RIs and PIs were measured by means of color duplex Doppler sonography and correlated with clinical and laboratory findings and with morpological abnormalities at B-mode ultrasonography. Results: Mean RI in the control subjects was 0.59±0.03 (±SD) and in the patients 0.71±0.11, (p<0.01). Mean PI in the controls was 1.00±0.11 and in the patients 1.69±0.21, (p<0.01). Elevated RIs and PIs heralded a progression of ADPKD. Doppler indices correlated significantly with renal function tests and morphological changes in the affected kidneys at ultrasound. Significantly higher RIs (p<0.01) and PIs (p<0.04) were measured in hypertensive ADPKD patients as compared to normotensive patients. Correlation of patient age and Doppler indices did not reach statistical significance. Conclusion: Doppler indices do reflect the increased RVR in patients with ADPKD and they correlate with renal function disturbance, with the development of systematic arterial hypertension, and with ultrasonographic abnormality of the kidney in these subjects.
KW - Autosomal dominant polycystic disease
KW - Duplex sonography
KW - Kidney, cysts
KW - Vascular resistance, ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=0031228047&partnerID=8YFLogxK
U2 - 10.1080/02841859709172421
DO - 10.1080/02841859709172421
M3 - Article
C2 - 9332241
AN - SCOPUS:0031228047
SN - 0284-1851
VL - 38
SP - 840
EP - 846
JO - Acta Radiologica
JF - Acta Radiologica
IS - 5
ER -