Renal vascular resistance in autosomal dominant polycystic kidney disease: Evaluation with color doppler ultrasound

B. Brkljacic, M. Sabljar-Matovinovic, K. Putarek, D. Soldo, J. Morovic-Vergles, Markus Hauser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate the performance of duplex Doppler ultrasonography in the assessment of renal vascular resistance (RVR) by measuring resistive indices (RIs) and pulsatility indices (PIs) in patients with autosomal dominant polycystic kidney disease (ADPKD), and to correlate the measured values with renal function and the presence of arterial hypertension. Materials and Methods: In 42 patients with ADPKD and 65 control subjects, RIs and PIs were measured by means of color duplex Doppler sonography and correlated with clinical and laboratory findings and with morpological abnormalities at B-mode ultrasonography. Results: Mean RI in the control subjects was 0.59±0.03 (±SD) and in the patients 0.71±0.11, (p<0.01). Mean PI in the controls was 1.00±0.11 and in the patients 1.69±0.21, (p<0.01). Elevated RIs and PIs heralded a progression of ADPKD. Doppler indices correlated significantly with renal function tests and morphological changes in the affected kidneys at ultrasound. Significantly higher RIs (p<0.01) and PIs (p<0.04) were measured in hypertensive ADPKD patients as compared to normotensive patients. Correlation of patient age and Doppler indices did not reach statistical significance. Conclusion: Doppler indices do reflect the increased RVR in patients with ADPKD and they correlate with renal function disturbance, with the development of systematic arterial hypertension, and with ultrasonographic abnormality of the kidney in these subjects.

Original languageEnglish
Pages (from-to)840-846
Number of pages7
JournalActa Radiologica
Volume38
Issue number5
DOIs
Publication statusPublished - 1997

Other keywords

  • Autosomal dominant polycystic disease
  • Duplex sonography
  • Kidney, cysts
  • Vascular resistance, ultrasonography

Fingerprint

Dive into the research topics of 'Renal vascular resistance in autosomal dominant polycystic kidney disease: Evaluation with color doppler ultrasound'. Together they form a unique fingerprint.

Cite this