Reconstructing an African haploid genome from the 18th century

Anuradha Jagadeesan; Ellen D. Gunnarsdóttir; S. Sunna Ebenesersdóttir; Valdis B. Gumundsdóttir; Elisabet Linda Thordardottir; Margrét S. Einarsdóttir; Hákon Jónsson; Jean Michel Dugoujon; Cesar Fortes-Lima; Florence Migot-Nabias; Achille Massougbodji; Gil Bellis; Luisa Pereira; Gísli Másson; Augustine Kong; Kári Stefánsson; Agnar Helgason

doi:10.1038/s41588-017-0031-6

Reconstructing an African haploid genome from the 18th century

Anuradha Jagadeesan, Ellen D. Gunnarsdóttir, S. Sunna Ebenesersdóttir, Valdis B. Gumundsdóttir, Elisabet Linda Thordardottir, Margrét S. Einarsdóttir, Hákon Jónsson, Jean Michel Dugoujon, Cesar Fortes-Lima, Florence Migot-Nabias, Achille Massougbodji, Gil Bellis, Luisa Pereira, Gísli Másson, Augustine Kong, Kári Stefánsson^*, Agnar Helgason

^*Corresponding author for this work

Faculty of Sociology, Anthropology and Folkloristics

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.

Original language	English
Pages (from-to)	199-205
Number of pages	7
Journal	Nature Genetics
Volume	50
Issue number	2
DOIs	https://doi.org/10.1038/s41588-017-0031-6
Publication status	Published - 1 Feb 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

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Jagadeesan, A., Gunnarsdóttir, E. D., Ebenesersdóttir, S. S., Gumundsdóttir, V. B., Thordardottir, E. L., Einarsdóttir, M. S., Jónsson, H., Dugoujon, J. M., Fortes-Lima, C., Migot-Nabias, F., Massougbodji, A., Bellis, G., Pereira, L., Másson, G., Kong, A., Stefánsson, K., & Helgason, A. (2018). Reconstructing an African haploid genome from the 18th century. Nature Genetics, 50(2), 199-205. https://doi.org/10.1038/s41588-017-0031-6

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abstract = "A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.",

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Jagadeesan, A, Gunnarsdóttir, ED, Ebenesersdóttir, SS, Gumundsdóttir, VB, Thordardottir, EL, Einarsdóttir, MS, Jónsson, H, Dugoujon, JM, Fortes-Lima, C, Migot-Nabias, F, Massougbodji, A, Bellis, G, Pereira, L, Másson, G, Kong, A, Stefánsson, K & Helgason, A 2018, 'Reconstructing an African haploid genome from the 18th century', Nature Genetics, vol. 50, no. 2, pp. 199-205. https://doi.org/10.1038/s41588-017-0031-6

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AU - Gumundsdóttir, Valdis B.

AU - Thordardottir, Elisabet Linda

AU - Einarsdóttir, Margrét S.

AU - Jónsson, Hákon

AU - Dugoujon, Jean Michel

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AU - Migot-Nabias, Florence

AU - Massougbodji, Achille

AU - Bellis, Gil

AU - Pereira, Luisa

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AU - Stefánsson, Kári

AU - Helgason, Agnar

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Reconstructing an African haploid genome from the 18th century

Abstract

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