Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13

Sigurdur Ingvarsson*, Charlotte Asker, Josiane Szpirer, Göran Levan, George Klein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat × mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalSomatic Cell and Molecular Genetics
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 1988

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