Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

Joeri Meijsen; Kejia Hu; Morten D. Krebs; Georgios Athanasiadis; Sarah Washbrook; Richard Zetterberg; Raquel Nogueira Avelar e Silva; John R. Shorter; Jesper R. Gådin; Jacob Bergstedt; David M. Howard; Weimin Ye; Yi Lu; Unnur A. Valdimarsdóttir; Andrés Ingason; Dorte Helenius; Oleguer Plana-Ripoll; John J. McGrath; Nadia Micali; Ole A. Andreassen; Thomas M. Werge; Fang Fang; Alfonso Buil

doi:10.1038/s41467-024-49507-3

Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

Joeri Meijsen^*, Kejia Hu, Morten D. Krebs, Georgios Athanasiadis, Sarah Washbrook, Richard Zetterberg, Raquel Nogueira Avelar e Silva, John R. Shorter, Jesper R. Gådin, Jacob Bergstedt, David M. Howard, Weimin Ye, Yi Lu, Unnur A. Valdimarsdóttir, Andrés Ingason, Dorte Helenius, Oleguer Plana-Ripoll, John J. McGrath, Nadia Micali, Ole A. AndreassenThomas M. Werge, Fang Fang, Alfonso Buil^*

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

Original language	English
Article number	5064
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-49507-3
Publication status	Published - Dec 2024

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© The Author(s) 2024.

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Meijsen, J., Hu, K., Krebs, M. D., Athanasiadis, G., Washbrook, S., Zetterberg, R., Avelar e Silva, R. N., Shorter, J. R., Gådin, J. R., Bergstedt, J., Howard, D. M., Ye, W., Lu, Y., Valdimarsdóttir, U. A., Ingason, A., Helenius, D., Plana-Ripoll, O., McGrath, J. J., Micali, N., ... Buil, A. (2024). Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. Nature Communications, 15(1), Article 5064. https://doi.org/10.1038/s41467-024-49507-3

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title = "Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians",

abstract = "Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.",

author = "Joeri Meijsen and Kejia Hu and Krebs, {Morten D.} and Georgios Athanasiadis and Sarah Washbrook and Richard Zetterberg and {Avelar e Silva}, {Raquel Nogueira} and Shorter, {John R.} and G{\aa}din, {Jesper R.} and Jacob Bergstedt and Howard, {David M.} and Weimin Ye and Yi Lu and Valdimarsd{\'o}ttir, {Unnur A.} and Andr{\'e}s Ingason and Dorte Helenius and Oleguer Plana-Ripoll and McGrath, {John J.} and Nadia Micali and Andreassen, {Ole A.} and Werge, {Thomas M.} and Fang Fang and Alfonso Buil",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41467-024-49507-3",

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Meijsen, J, Hu, K, Krebs, MD, Athanasiadis, G, Washbrook, S, Zetterberg, R, Avelar e Silva, RN, Shorter, JR, Gådin, JR, Bergstedt, J, Howard, DM, Ye, W, Lu, Y, Valdimarsdóttir, UA, Ingason, A, Helenius, D, Plana-Ripoll, O, McGrath, JJ, Micali, N, Andreassen, OA, Werge, TM, Fang, F & Buil, A 2024, 'Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians', Nature Communications, vol. 15, no. 1, 5064. https://doi.org/10.1038/s41467-024-49507-3

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AU - Athanasiadis, Georgios

AU - Washbrook, Sarah

AU - Zetterberg, Richard

AU - Avelar e Silva, Raquel Nogueira

AU - Shorter, John R.

AU - Gådin, Jesper R.

AU - Bergstedt, Jacob

AU - Howard, David M.

AU - Ye, Weimin

AU - Lu, Yi

AU - Valdimarsdóttir, Unnur A.

AU - Ingason, Andrés

AU - Helenius, Dorte

AU - Plana-Ripoll, Oleguer

AU - McGrath, John J.

AU - Micali, Nadia

AU - Andreassen, Ole A.

AU - Werge, Thomas M.

AU - Fang, Fang

AU - Buil, Alfonso

PY - 2024/12

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AB - Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

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Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

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