PUVA and cancer: A case-control study

B. Lindelof*, B. Sigurgeirsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


A detailed case-control study was carried out on 24 PUVA-treated patients with squamous cell cancer of the skin, and on an accurately matched control population of 96 PUVA-treated patients. Possible co-carcinogens, such as prior therapy with tar, ultraviolet-B, ionizing radiation, methotrexate and arsenic, were investigated. The only statistically significant association to emerge was that of prior therapy with methotrexate: relative risk 3.5; 95% confidence interval 1.2-9.9. Our data suggest that prior therapy with methotrexate might be a risk factor for skin cancer in PUVA-treated patients.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalBritish Journal of Dermatology
Issue number1
Publication statusPublished - 1993


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