Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

Valtyr S. Thors; Marc B. Bierings; Willem J.G. Melchers; Paul E. Verweij; Tom F.W. Wolfs

doi:10.1097/INF.0b013e3182037879

Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

Valtyr S. Thors, Marc B. Bierings, Willem J.G. Melchers, Paul E. Verweij, Tom F.W. Wolfs

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

Original language	English
Pages (from-to)	268-270
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	3
DOIs	https://doi.org/10.1097/INF.0b013e3182037879
Publication status	Published - Mar 2011

Other keywords

antifungal drugs
Aspergillus fumigatus
azole resistance
hematopoietic stem-cell transplantation
invasive aspergillosis

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10.1097/INF.0b013e3182037879

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title = "Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy",

abstract = "A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.",

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AU - Thors, Valtyr S.

AU - Bierings, Marc B.

AU - Melchers, Willem J.G.

AU - Verweij, Paul E.

AU - Wolfs, Tom F.W.

PY - 2011/3

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AB - A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

KW - antifungal drugs

KW - Aspergillus fumigatus

KW - azole resistance

KW - hematopoietic stem-cell transplantation

KW - invasive aspergillosis

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JF - Pediatric Infectious Disease Journal

IS - 3

ER -

Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

Abstract

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