Psoriasis - as an autoimmune disease caused by molecular mimicry

Helgi Valdimarsson; Ragna H Thorleifsdottir; Sigrun L Sigurdardottir; Johann E Gudjonsson; Andrew Johnston

doi:10.1016/j.it.2009.07.008

Psoriasis - as an autoimmune disease caused by molecular mimicry

Helgi Valdimarsson, Ragna H Thorleifsdottir, Sigrun L Sigurdardottir, Johann E Gudjonsson, Andrew Johnston

Landspitali - The National University Hospital of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Psoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.

Original language	English
Journal	Trends in Immunology
DOIs	https://doi.org/10.1016/j.it.2009.07.008
Publication status	Published - Oct 2009

Other keywords

Antigens, Bacterial
Autoimmune Diseases
Bacterial Outer Membrane Proteins
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Carrier Proteins
Dermis
Epidermis
Humans
Keratins
Molecular Mimicry
Palatine Tonsil
Peptidoglycan
Psoriasis
Streptococcal Infections
Streptococcus
Superantigens
Tonsillitis

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10.1016/j.it.2009.07.008

http://dx.doi.org/10.1016/j.it.2009.07.008

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title = "Psoriasis - as an autoimmune disease caused by molecular mimicry",

abstract = "Psoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.",

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author = "Helgi Valdimarsson and Thorleifsdottir, {Ragna H} and Sigurdardottir, {Sigrun L} and Gudjonsson, {Johann E} and Andrew Johnston",

year = "2009",

month = oct,

doi = "10.1016/j.it.2009.07.008",

language = "English",

journal = "Trends in Immunology",

issn = "1471-4906",

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AU - Valdimarsson, Helgi

AU - Thorleifsdottir, Ragna H

AU - Sigurdardottir, Sigrun L

AU - Gudjonsson, Johann E

AU - Johnston, Andrew

PY - 2009/10

Y1 - 2009/10

N2 - Psoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.

AB - Psoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.

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KW - Autoimmune Diseases

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KW - CD4-Positive T-Lymphocytes

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KW - Dermis

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KW - CD8-Positive T-Lymphocytes

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KW - Streptococcal Infections

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U2 - 10.1016/j.it.2009.07.008

DO - 10.1016/j.it.2009.07.008

M3 - Article

C2 - 19781993

SN - 1471-4906

JO - Trends in Immunology

JF - Trends in Immunology

ER -

Psoriasis - as an autoimmune disease caused by molecular mimicry

Abstract

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