Protective effects of monoclonal antibodies against parainfluenza virus type 3-induced brain infection in hamsters

R. Rydbeck, A. Love, E. Norrby

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A collection of monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins of parainfluenza virus type 3 (PIV3) was used for passive immunization of intracerebrally infected newborn hamsters. A significant degree of protection was obtained with MAbs against both the HN and F viral proteins, but no individual antibody conferred complete protection against disease. MAbs against different epitopes provided different degrees of protection. A MAb to the Sendai virus HN protein was found to confer protection against PIV3 brain infection.

Original languageEnglish
Pages (from-to)1019-1024
Number of pages6
JournalJournal of General Virology
Volume69
Issue number5
DOIs
Publication statusPublished - 1988

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